Highly Validated Approaches to Highly Unmet Needs.

Developing Treatments for Severe Liver Disease.

about

Inipharm is a biopharmaceutical company focused on discovering and developing therapies for severe liver diseases. Inipharm's lead program is focused on the highly validated, genetically-defined target, HSD17B13.

There is extensive, consistent evidence that genetic variants in expression of HSD17B13 are associated with significantly lower rates and severity of multiple liver diseases. Building on these novel insights into the biologic activity of HSD17B13, Inipharm is advancing a pipeline of small-molecule therapies that target the activity of this protein.

our science

Inipharm is developing small-molecule inhibitors of HSD17B13 to treat fibrotic liver diseases. Inipharm's inhibitors have been shown in human liver cell-based systems to have anti-fibrotic effects.


  • HSD17B13 has been identified as a novel target for NASH and driver of liver disease from a genome wide association study.
  • Loss of function variants in HSD17B13 are associated with reduced risk incidence and/or the severity of numerous liver diseases.
  • Importantly, HSD17B13 has been shown to be involved in pathways associated with lipotoxicity, inflammation, and fibrosis.
HSD17B13 Disease Association Chart
SOURCES: Gellert-Kristensen 2019; Abul-Husn 2018; Kozlitina 2018; About 2018; Ferenci 2019, Yang 2020 Hepatol; About 2018 NEJM

INI-822, development candidate

  • Reduced fibrotic markers in human liver cell model
  • Improved liver enzymes in multiple in vivo models
  • Replicated lipidomic changes seen with protective HSD17B13 variant
HSD17B13 Disease Association Chart
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leadership

board of directors

scientific advisory board

investors

  • Frazier Life Sciences logo
  • 5AM Ventures logo
  • Platanus logo

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